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Overview of Cialis (tadalafil) and Its Uses

Cialis (tadalafil) is a prescription medication that belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. It is used primarily for the treatment of erectile dysfunction and pulmonary arterial hypertension, and it has been approved for the treatment of the symptoms associated with benign prostatic hyperplasia (BPH).

Mechanism of Action of Cialis (Tadalafil) in Erectile Dysfunction

Cialis (tadalafil) works by increasing blood flow to the penis, allowing for a more rigid erection when sexually aroused. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

Indications for Use

Cialis (tadalafil) is used for the treatment of erectile dysfunction in men. It is primarily indicated for the treatment of benign prostatic hyperplasia (BPH) and the treatment of erectile dysfunction associated with pulmonary arterial hypertension (PAH).

Dosage and Administration

The dosage of Cialis (tadalafil) for men varies depending on the individual’s needs and the severity of their erectile dysfunction.

Side Effects of Cialis (Tadalafil) in Erectile Dysfunction

The common side effects of Cialis (tadalafil) include:

  • Flushing (sense of warmth in the face, ears, and neck)
  • Headache
  • Dizziness
  • Nausea
  • Back pain
  • Indigestion
  • Muscle pain
  • Upset stomach
  • Stuffy nose

In rare cases, Cialis (tadalafil) may cause priapism, a prolonged and painful erection, which can lead to permanent damage to your penis.

Precautions and Warnings

Before using Cialis (tadalafil), it is important to inform your doctor about any medical conditions or previous treatments you have experienced.

It is advisable to avoid sexual activity if you have a heart condition or if you have recently had a stroke, blood clot, or liver problems.

Cialis (tadalafil) should also be used with caution in patients with a history of heart disease, high blood pressure, or uncontrolled high cholesterol.

Possible Side Effects of Cialis (Tadalafil) in Erectile Dysfunction

  • Mild dryness in the chest or face
  • Vomiting
  • Nasal congestion

Serious side effects such as sudden vision loss, priapism (prolonged and painful erection), or an erection lasting more than four hours (priapism) may occur. If you experience any of these side effects, seek immediate medical attention.

Risks and Side Effects of Cialis (Tadalafil) in Erectile Dysfunction

The following are some of the possible risks and side effects of Cialis (tadalafil):

  • Heart disease or heart failure
  • High or low blood pressure
  • Low testosterone levels
  • Recent stroke or heart attack
  • Low levels of calcium in the blood
  • Low levels of potassium in the blood

In some cases, Cialis (tadalafil) may cause vision changes, such as blurred or double vision, or loss of vision. These side effects are rare but can occur.

Before using Cialis (tadalafil), it is important to educate your doctor about all other medications you are currently taking.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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Additionally, let your health care provider know if you are pregnant or plan to become pregnant. Cialis can interact with bodily substances, making potentially serious adverse reactions worse.

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Cialis may occasionally cause serious side effects. Talk to your health care provider if you experience these. Cialis can cause a rare side effect, which can be rare but is rarer if you are on medication that can interact with Cialis.

Can my provider prescribe Cialis?

Cialis can cause a rare side effect; however, it can be serious. This is due to its impact on blood vessels in the penis, nerves, and the smooth muscle of the penis. This can make it difficult to get and maintain an erection. Cialis can also cause a condition called phosphodiesterase type 5 (PDE5) to be inhibited. This means that Cialis can affect blood flow to the penis, making it difficult to get an erection. Cialis can also cause a condition called penile vascular resistance decrease.

If you experience any unusual side effects, seek medical attention immediately.

As with all prescription medications, inform your doctor if you have any pre-existing medical conditions, especially heart know-how, allergens, or other medication interactions. Cialis can also cause a condition called penile tissue injury. This can make keeping an erection difficult. Cialis can also cause a condition called penile fibrosis. This condition affects the men’s penis and can lead to erectile dysfunction. Cialis can also cause a condition called priapism (prolonged and painful erection). If you experience these, it is important to seek medical attention immediately.

Does the can interact with Cialis?

Cialis can interact with certain medications, including some supplements. This may affect how it is broken down by the enzymes in the medication. As with all prescription medications, inform your doctor if you are taking Cialis.

Kuala lumpu, Turkey, March 14, 2024 (GLOBE NEWSWIRE) -- Cipla Ltd. (Nasdaq: CIL) (“Cipla” or “Cipla” or “the Company”) today announced that it has received regulatory approval from the United States Food and Drug Administration (“FDA”) for its (““) tadalafil-containing product Cialis, a pharmaceutical product used in the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). Cialis is a branded version of Cialis, a well-known ED treatment in Turkey and internationally. The Company is also a global leader in its tadalafil product line, with over 6 million transactions and more than $1 billion of sales in 2024 and 2025. The Company is a global leader in its tadalafil product line and a market leader in the erectile dysfunction (ED) treatment market, with over 5.7 billion USD in sales annually and has a market share of around 3% of the global erectile dysfunction (ED) market.

About Cipla

Cipla is a global leader in the production, marketing, and distribution of a broad range of products used in the treatment of erectile dysfunction. In 2024, Cipla accounted for approximately $1.2 billion of the global erectile dysfunction (ED) market revenue, and approximately $1.7 billion of the market revenue from erectile dysfunction treatments globally is attributable to Cialis. The Company is a member of the Pfizer family of drug brands. Cipla’s manufacturing processes and manufacturing facilities are located in Israel, Poland, Spain, Turkey, and Bulgaria. Cipla is a member of the largest pharmaceutical companies in the world and is the largest producer of generic tadalafil. The Company is a key player in the production, marketing, and distribution of tadalafil products in Turkey and worldwide.

About Cialis

Cialis is a tadalafil-containing product used in the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). The company is a leader in the treatment of erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). Cialis contains a phosphodiesterase type 5 inhibitor that helps to relax the smooth muscles in the penis to improve blood flow, thereby facilitating the achievement and maintenance of an erection.

The Company is a global leader in its tadalafil product line, with over 6 million transactions and more than $1 billion of sales in 2024 and 2025.

The company is a leading player in the production, marketing, and distribution of tadalafil products in Turkey and worldwide.

About Teva Pharmaceutical Industries Ltd.

Teva Pharmaceutical Industries Ltd. is a global leader in the production, marketing, and distribution of generic tadalafil-containing products. The Company is a global leader in its tadalafil product line and a market leader in the erectile dysfunction (ED) treatment market, with over 6 million transactions and more than $1 billion of sales in 2024 and 2025.

The Company is a leading player in the production, marketing, and distribution of generic tadalafil products in Turkey and worldwide. The Company is a global leader in its tadalafil product line and a market leader in the erectile dysfunction (ED) treatment market, with over 5.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
RicanMix () is a combination of 10Combination Products. is used to treat erectile dysfunction by increasing blood flow to the penis, helping men achieve and maintain a harder, longer-lasting erection. It may be prescribed in certain cases for hypertension and pulmonary arterial hypertension. This combination is intended to improve blood flow to the penis, enabling men with erectile dysfunction to achieve and maintain an erection during sexual activity.
  • Cialis (tadalafil) can interact with certain foods and beverages, so it is contraindicated in these conditions.
  • C.

    Tadalafil (Cialis) can interact with certain foods and beverages, so it is contraindicated in these conditions.

    Such as:

    • Alcohol: Though not a direct interaction, combining Cialis with Cialis might worsen side effects like headaches or increase tadalafil levels in your blood.